Heat a large skillet over medium-high heat for about 2 minutes.

Add the ground beef, breaking it apart with a spatula. Cook for 6-8 minutes or until it's no longer pink in the center, looking browned and crumbly.

Drain any excess fat for a leaner filling.

Once the beef is cooked, sprinkle in salt, black pepper, garlic powder, onion powder, and Worcestershire sauce. Stir well to combine and cook for an additional 2 minutes.

Take your thick-cut bread and spread butter or mayonnaise generously on one side of each slice.

On a clean skillet over medium heat, place the bread slices butter-side-down. Layer each with cheddar and mozzarella cheese.

Spoon the seasoned ground beef evenly over the cheese on one slice, then add another layer of mozzarella on top of the beef.

Top with a second slice of bread, butter-side-up.

Carefully flip the sandwich once the cheese begins to melt, about 3-4 minutes. Grill each side for an additional 3-4 minutes.

Remove the sandwiches from the skillet and let them rest for about 1 minute.

Slice the sandwiches in half and serve warm.