Preheat your oven to 375°F (190°C) and prepare a loaf pan.

In a medium bowl, mix the boxed dry stuffing mix with milk and let it sit for about 5 minutes.

Combine ground turkey, softened stuffing, egg, chopped onion, Worcestershire sauce, garlic powder, onion powder, dried thyme, salt, and black pepper in a large mixing bowl.

Transfer the meat mixture into the prepared loaf pan, shaping it evenly.

Mix ketchup, brown sugar, and Dijon mustard; spread half over the meatloaf.

Bake uncovered in the preheated oven for 50 to 55 minutes, until the internal temperature reaches 165°F (74°C).

Let it rest for about 10 minutes before serving.